PReS-FINAL-2053: Vitamin D receptor polymorphisms in a cohort of Italian patients with juvenile idiopathic arthritis
نویسندگان
چکیده
Methods We recruited 63 Italian children, adolescents and young adults with JIA (mean age 16.21 + 7.11 SD yrs, 51 female and 12 males, female/male ratio 4.25 from 1 Unit of Paediatric Rheumatology and 1 Unit of Rheumatology, Transition Clinic. After informed consent, during routine laboratory tests, their genomic DNA was extracted from peripheral blood leukocytes, to analyze VDR polymorphisms by PCR-based sequencing (CDX2 in the promoter region) and PCR-based enzymatic digestions (FokI in exon 2, BsmI and ApaI in intron 8, and TaqI in exon 9). An Italian population of 2221 unrelated individuals without JIA was used as healthy controls.
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